In his second letter to Timothy, as Paul neared the end of his life, he was again in prison. The fact that he referred to his “chain” in verse 16 indicates that his circumstances were far worse than the house arrest of his first imprisonment.
During this imprisonment, the apostle had been deserted by some. He mentions individuals in Asia, including Phygellus and Hermogenes. These two are mentioned only here, and we know nothing else about them.
In contrast, we have Onesiphorus. While others deserted Paul, this man sought to help him. In doing this, Onesiphorus helped not only Paul, but the Lord Himself (cf. Matthew 15:36). We are told he “refreshed” Paul. Consider the relief that comes amidst dark despair when your brethren bring encouragement and help.
When Paul received such encouragement, he was quick to note that such diligence brings benefits to the one offering the gift (cf. Philippians 4:17). Here Paul prayed such for Onesiphorus and his family.
